Photodynamic therapy and topical steroid effects upon immune regulatory cells among patients with oral lichen planus

Document Type : Original Article

Authors

1 Oral Medicine, Periodontology, Diagnosis and Oral Radiology Faculty of Dental Medicine Al-Azhar University, Egypt

2 Department of Oral Medicine, Periodontology, Oral Radiology and Oral Diagnosis Faculty of Dental Medicine (Boys Cairo) Al-Azhar University

3 Department of oral medicine, periodontology, oral Radiology and oral Diagnosis faculty of dental medicine Al-Azhar university , Egypt

Abstract

Objective: To evaluate the effectiveness of the photodynamic therapy (PDT) in comparison with topical corticosteroids upon immune regulatory cells of patients oral lichen planus.
Subjects and methods: Twenty patients with clinical and histological diagnosis of EOLP were divided into two equal groups. Group A: (control group) were instructed to use topical corticosteroid, Group B :( study group) received PDT using diode laser 635 nm mediated by toluidine blue (TB), and before starting the treatment five milliliters of peripheral venous blood was taken from both patients groups and withdrawn into an EDTA- containing test tube to prevent coagulation. These procedures were performed after three months and six months of treatment for both topical corticosteroids and PDT treated patients to detect changes occurs before and after treatment.
Results: a statistically significant difference was reported between baseline and follow -up periods. Where both groups showed a remarkable reduction in pain, size of lesions, and CD4:CD8 ratio showed statistically significant decrease during follow up periods.
Conclusions: Photodynamic therapy is an effective treatment and it can be considered as an alternative method for TC in treatment of erosive-atrophic OLP and effectively regulates the distribution of CD4+ T cells and CD8+ T cells
Keywords: oral lichen planus, photodynamic therapy, topical steroid, immune regulatory cells.

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Al-Azhar Journal of Dental Science
Volume 26, Issue 1 - Serial Number 1
January - Oral Medicine & Surgical Sciences Issue (Oral Medicine, Oral & Maxillofacial Surgery, Oral Pathology, Oral Biology)
January 2023
Pages 75-83

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