Therapeutic efficacy of targeted paclitaxel loaded on albumin nanoparticles on DMBA induced oral squamous cell carcinoma

Document Type : Original Article

Authors

1 Oral and Dental Pathology Department, Faculty of Dental Medicine (Boys- Cairo), Al-Azhar University, Egypt

2 Oral and Dental Pathology Department, Faculty of Dental Medicine (Boys-Cairo), Al-Azhar University, Egypt4.

3 Oral and Dental Pathology Department, Faculty of Dental Medicine (Boys-Cairo), Al-Azhar University, Egypt.

Abstract

Purpose: This research was aimed to determine therapeutic efficacy of targeted paclitaxel loaded on albumin nanoparticles on DMBA induced oral squamous cell carcinoma (OSCC).
Subjects & methods: The thirty Syrian male hamsters had been separated into three groups, each with 10 members, that had been all equal. GI: To serve as negative controls, animals were left untreated. For fourteen weeks, seven,twelve-dimethylbenz (a) anthracene was applied 3 times per week to right pouches of animals in groups GII and GIII. In GII: No additional therapy had been administered. Whilst animals in GIII had been injected intraperitoneally (IP) with nanoparticles ab blbumin bound (NAB) paclitaxel (PTX) (ten mg/kg) two times per week for2 weeks. After termination of experiment, gross observations had been recorded. Then, animals had been euthanized, all pouches had been surgically excised, fixed, & processed for hematoxylin & eosin stain examination & immunohistochemical staining utilizing (BCL2) as anti-apoptotic marker.
Results: In this research, outcomes discovered some variability across medicated G (GIII)contrasted toGII. IHC of BCL2 highly revealed variation among GI & GII as well as GII & GIII (p value < 0.001).
Conclusion:
Conjugation of folate on surface of NAB improved cellular uptake, infiltration, & blood brain barrier penetration. folate modified NAB had been confirmed to be more efficient to induce apoptosis of OSSC with encapsulation of PTX.

Keywords

Main Subjects

Al-Azhar Journal of Dental Science
Volume 28, Issue 1 - Serial Number 1
January - Oral Medicine & Surgical Sciences Issue (Oral Medicine, Oral & Maxillofacial Surgery, Oral Pathology, Oral Biology)
January 2025
Pages 71-80

Files

Share

How to cite

Statistics