Effect of low-level laser therapy on cisplatin induced cytotoxicity in parotid gland of rats.

Document Type : Original Article

Authors

1 Department of oral biology alazhar university Cairo boys Egypt

2 oralbiology department alazhar university

3 oral biology department alazhar university

Abstract

Objective: the current study was designed to evaluate the therapeutic efficacy of low-level laser therapy (LLLT) on parotid glands following cytotoxicity produced by cisplatin in rats. Subject and Methods: The study employed a sample of 36 adult males Sprague-Dawley rats were divided into three groups, each consisting of 12 rats. Group I: control group received phosphate-buffered saline. Group II: referred to as the cisplatin group, was administered a solitary intraperitoneal injection of the cisplatin medication at a dosage of 10mg/kg. Group III: received the dose of cisplatin used in group II, then exposed to a single session of LLLT on day 3 after cisplatin administration. After cisplatin injection and low-level laser irradiation, animals were sacrificed at 7 and 14 days. The sacrifice was examined histologically and ultra structurally. Results: The experimental LLL-treated group showed some improvement in the gland but could not regenerate to normal arctecture. Conclusion: This study proved that LLL cannot improve cytotoxicity induced by cisplatin in parotid glands.

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Al-Azhar Journal of Dental Science
Volume 28, Issue 2 - Serial Number 2
April - Oral Medicine & Surgical Sciences Issue (Oral Medicine, Oral & Maxillofacial Surgery, Oral Pathology, Oral Biology)
April 2025
Pages 239-248

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