Association between Vitamin D receptor Taq I (rs731236) gene polymorphism and dental caries susceptibility in Egyptian children.

Document Type : literature

Authors

1 Azhar university faculty of dentistry pediatric department

2 Assistant professor of Pedodontics and Oral Health Faculty of Dental Medicine, Boys, Cairo Al-Azhar University

3 Department of Pedodontics and Oral Health Faculty of Dental Medicine, Boys, Cairo Al-Azhar University

4 Biochemistry and Molecular biology, Faculty of Pharmacy, Azhar University, Cairo , Egypt

Abstract

Objective: Dental caries is a complex infectious illness resulting from the interaction of several genetic and environmental variables. The purpose of this work is to evaluate the association among the genetic polymorphism TaqI (rs731236) in vitamin D receptor (VDR) with susceptibility to dental caries and/or severity in Egyptian children Subject and Methods: 300 Egyptian children with dental caries were participated in this study. Another hundred children in good health were included as controls. The oral and dental state of all individuals was assessed using the WHO standards, and dmft/DMFT Index was used for evaluating clinical information. Genomic DNA was extracted from buccal swabs, and the VDR TaqI (rs731236) gene polymorphism was determined by qRT-PCR.
Results: The genotypic distribution and allelic frequency of both A and G alleles were evaluated in controls and dental caries subjects under different genetic models. A substantial association among the G allele of the VDR gene (rs731236) and dental caries susceptibility and/or severity were found compared to controls (p= 0.01). Moreover, a significant association with dental caries severity risk was observed under one of the co-dominant models used (GG versus AA, p= 0.01), dominant model (p= 0.02) and recessive model (p= 0.045). There was no significant association between the other co-dominant model utilized in this study (AG versus AA, p= 0.08) and the over-dominant model (p= 0.36) contrasted to the controls.
Conclusion: VDR-Taq I gene polymorphism might be correlated with dental caries susceptibility and/or severity in Egyptian children with raised risk of dental caries.

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Al-Azhar Journal of Dental Science
Volume 28, Issue 3 - Serial Number 3
July - Pediatric Dentistry & Orthodontics Issue (Pediatric Dentistry, Orthodontics)
July 2025
Pages 507-515

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